Detailed Mechanism Funding and Narrative

Years of mechanism: 2010 2011 2012

Details for Mechanism ID: 9515
Country/Region: South Africa
Year: 2010
Main Partner: TogaLabs
Main Partner Program: NA
Organizational Type: Private Contractor
Funding Agency: HHS/CDC
Total Funding: $2,172,108

1. A unique approach to implementing HIV laboratory measurement in rural, resource poor primary health care settings.

2. South Africa is dealing with an advanced epidemic of HIV-1 infection and AIDS with an estimated 500,000 new infections per annum and the current imperative to get 1 million people on antiretroviral therapy (ART).The problem is huge and requires courageous and creative interventions with involvement of all of civil society.

3. Laboratory measurement underpins all aspects of HIV management including basic care of patients, administration and evaluation of programmes and even impact on whole communities. While the bulk of HIV management must reside at primary health level, the current pathology paradigm excludes contemplation of performing key tests such as CD4+ lymphocyte level and HIV viral load at primary health level on the basis of feasibility and cost. In rural and resource poor settings this complicates the provision of quality care and places stress on centrally based laboratory facilities.

4. One of the benefits of this model is that laboratory measurement empowers peripheral facilities to deploy task-shifting or down-referral, thus extend the healthcare footprint for HIV (and by implication for other chronic diseases as well) without compromising the quality of patient care.

5. Prior to the commencement of this programme Toga laboratories had evolved a facilitated, peripheral

laboratory solution utilising purpose built and converted shipping containers or modified buildings, together with highly functional communication. This solution continues to be operational in three different settings, including in association with a Government programme in the Western Cape. Experience gained during the implementation of the proof of concept confirmed that clinical support based on a comprehensive menu of appropriate HIV pathology tests performed in a community setting is both affordable and technically feasible.

6. The scope of this project includes the placement of 15 such peripheral laboratories in association with established and growing clinical HIV programmes in rural and/or resource poor settings, each capable of supporting 8-10,000 people on ART.

7. The qualification of candidate sites for the programme is best contextualized within the development of the concept of the Autonomous Treatment Centre where all aspects of HIV are managed within a community clinic setting. The service includes the ability to offer infant diagnosis in support of PMTCT programmes.

8. The complex of activities and expenditure includes: 8.1. Project management. 8.2. Laboratory container conversion. 8.3. Information systems for laboratory test requesting and resulting. 8.4. Configuration and placement. 8.5. Staffing and human resource support. 8.6. Implementation and operational management. 8.7. Training and continuous professional development. 8.8. Quality system management and accreditation (SANAS [South African National Accreditation System] or ISO/IEC 17025 progressing to ISO 15189 standards). 8.9. Itinerant and backup support. 8.10. Site sustainability planning.

9. The successful implementation of this project may be determined by reference to the 'deliverables' listed below. 9.1. Deployment of containerised laboratories. 9.2. Empowerment through informatics. 9.3. Test and patient metrics. 9.4. Skills development. 9.5. Partner leveraging.

Funding for Laboratory Infrastructure (HLAB): $2,172,108

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